Meetings can include audio, video and/or sharing of PPT or other documents (content). How does Skype for Business work? Skype for Business is set-up to work either for ad hoc connections to other users or by using the Outlook calendar for scheduled meetings. You can use Skype for Business from nearly any Windows PC or mobile device (Lync on Macs or mobile devices), on campus or anywhere in the world you have Internet access. General: What is Skype for Business? Skype for Business is an easy-to-use interface that allows users to communicate through text chat, voice calls, video calls and online meetings. IT Strategic Advisory Committee (ITSAC).